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04-03-2020, 10:06pm | #181 | |||||||
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04-04-2020, 10:18am | #182 | ||||||
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Interesting use of anticoagulants in specific critically ill patients.
So many fascinating approaches to treatment in this bizarre virus. https://www.practiceupdate.com/conte...HcqG_F3d1R84cw |
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04-04-2020, 10:26am | #183 | ||||||
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Governor Cuoma is bragging about China and the great job they did at isolating the virus to WuHan province. If he genuinely believes this, why has he not locked down the state and not allowed anyone to leave New York?
Cuomo said the MTA will continue to run city subways, buses and Metro-North and Long Island Rail Road trains. The agency announced Friday it will allow backdoor boarding on local buses beginning Monday to help protect bus drivers from exposure. Why is mass transit still functioning? Ridiculous I'm fkn tired of hearing about masks and testing and hospital beds. START GIVING MEDS TO ALL !!! They have a drug that is showing results. How about tents set up to pass out meds instead of tests? |
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04-04-2020, 10:47am | #184 | |||||||
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As to your suggestion to hand out "meds to all". 1) There is currently not enough supply to continue to treat the critically ill as well as give to patients that need it for their autoimmune diseases. We have used it on all those that could be on it in our hospital and we have still lost many patients, helpful but by no means 100% effective. We are also utilizing multiple antivirals that are quite safe and showing some promising results. 2) Both the hydroquinone and the azithromycin are not meds that come without significant contraindications as well as interaction with meds people are already on. 3) The antimalarial drugs have shown to provide some good prophylaxis to infection, so for those that are candidates to take, and when there is an adequate supply, that would be something to consider. For reference, below is the list of complications and contraindications and well as interactions for the antimalarial. SIDE EFFECTS The following adverse reactions have been identified during post-approval use of PLAQUENIL or other 4-aminoqunoline compounds. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. Blood and lymphatic system disorders : Bone marrow failure, anemia, aplastic anemia, agranulocytosis, leukopenia, and thrombocytopenia. Hemolysis reported in individuals with glucose-6- phosphate dehydrogenase (G-6-PD) deficiency. Cardiac disorders : Cardiomyopathy which may result in cardiac failure and in some cases a fatal outcome (see WARNINGS and OVERDOSAGE). PLAQUENIL prolongs the QT interval. Ventricular arrhythmias and torsade de pointes have been reported in patients taking PLAQUENIL (see OVERDOSAGE and DRUG INTERACTIONS). Ear and labyrinth disorders : Vertigo, tinnitus, nystagmus, nerve deafness, deafness. Eye disorders : Irreversible retinopathy with retinal pigmentation changes (bull's eye appearance), visual field defects (paracentral scotomas) and visual disturbances (visual acuity), maculopathies (macular degeneration), decreased dark adaptation, color vision abnormalities, corneal changes (edema and opacities) including corneal deposition of drug with or without accompanying symptoms (halo around lights, photophobia, blurred vision). Gastrointestinal disorders : Nausea, vomiting, diarrhea, and abdominal pain. General disorders and administration site conditions : Fatigue. Hepatobiliary disorders : Liver function tests abnormal, hepatic failure acute. Immune system disorders : Urticaria, angioedema, bronchospasm Metabolism and nutrition disorders : Decreased appetite, hypoglycemia, porphyria, weight decreased. Musculoskeletal and connective tissue disorders : Sensorimotor disorder, skeletal muscle myopathy or neuromyopathy leading to progressive weakness and atrophy of proximal muscle groups, depression of tendon reflexes and abnormal nerve conduction. Nervous system disorders : Headache, dizziness, seizure, ataxia and extrapyramidal disorders such as dystonia, dyskinesia, and tremor have been reported with this class of drugs. Psychiatric disorders : Affect/emotional lability, nervousness, irritability, nightmares, psychosis, suicidal behavior. Skin and subcutaneous tissue disorders : Rash, pruritus, pigmentation disorders in skin and mucous membranes, hair color changes, alopecia. Dermatitis bullous eruptions including erythema multiforme, Stevens-Johnson syndrome, and toxic epidermal necrolysis, drug reaction with eosinophilia and systemic symptoms (DRESS syndrome), photosensitivity, dermatitis exfoliative, acute generalized exanthematous pustulosis (AGEP). AGEP has to be distinguished from psoriasis, although PLAQUENIL may precipitate attacks of psoriasis. It may be associated with pyrexia and hyperleukocytosis. To report SUSPECTED ADVERSE REACTIONS, contact Concordia Pharmaceuticals Inc. at 1- 877-370-1142 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch. DRUG INTERACTIONS Digoxin Concomitant PLAQUENIL and digoxin therapy may result in increased serum digoxin levels: serum digoxin levels should be closely monitored in patients receiving combined therapy. Insulin Or Antidiabetic Drugs As PLAQUENIL may enhance the effects of a hypoglycemic treatment, a decrease in doses of insulin or antidiabetic drugs may be required. Drugs That Prolong QT Interval And Other Arrhythmogenic Drugs PLAQUENIL prolongs the QT interval and should not be administered with other drugs that have the potential to induce cardiac arrhythmias. Also, there may be an increased risk of inducing ventricular arrhythmias if PLAQUENIL is used concomitantly with other arrhythmogenic drugs. Mefloquine And Other Drugs Known To Lower The Convulsive Threshold PLAQUENIL can lower the convulsive threshold. Co-administration of PLAQUENIL with other antimalarials known to lower the convulsion threshold (e.g., mefloquine) may increase the risk of convulsions. Antiepileptics The activity of antiepileptic drugs might be impaired if co-administered with PLAQUENIL. Methotrexate Combined use of methotrexate with PLAQUENIL has not been studied and may increase the incidence of adverse effects. Cyclosporin An increased plasma cyclosporin level was reported when cyclosporin and PLAQUENIL were co-administered. The following interactions have been observed on treatment with the structurally related substance chloroquine phosphate, and therefore cannot be ruled out for hydroxychloroquine. Praziquantel Chloroquine has been reported to reduce the bioavailability of praziquantel. Antacids And Kaolin Antacids and kaolin can reduce absorption of chloroquine; an interval of at least 4 hours between intake of these agents and chloroquine should be observed. Cimetidine Cimetidine can inhibit the metabolism of chloroquine, increasing its plasma level. Concomitant use of cimetidine should be avoided. Ampicillin In a study of healthy volunteers, chloroquine significantly reduced the bioavailability of ampicillin. |
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04-04-2020, 11:12am | #185 | ||||||
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Basically if you die of regular flu in Ohio like happens thousands of times each year, they are going to put you down for the 'rona. And I'm sure Ohio isn't the only place doing this. Gotta get those numbers up! |
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04-04-2020, 2:21pm | #186 | ||||||
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Huh.
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04-04-2020, 2:44pm | #187 | |||||||
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04-04-2020, 2:51pm | #188 | ||||||
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04-04-2020, 2:57pm | #189 | ||||||
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Another interesting treatment that has been used in other SARS infections. Nitrous Oxide.
I will volunteer for the study! 😂🤣😂 https://pubmed.ncbi.nlm.nih.gov/15650225/ |
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04-04-2020, 3:02pm | #190 | |||||||
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What's the difference? |
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04-04-2020, 3:05pm | #191 | ||||||
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Montana had three new cases in the last 24 hours... when does the exponential start?
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04-04-2020, 3:07pm | #192 | ||||||
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04-04-2020, 3:13pm | #193 | ||||||
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04-04-2020, 3:25pm | #194 | ||||||
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The irony is that China is doing the exact opposite - reporting anything except COVID-19 in order to support the CCPs narrative that they have beaten the Wuhan virus.
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04-04-2020, 3:27pm | #195 | ||||||
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04-04-2020, 3:30pm | #196 | ||||||
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Google machine...
25.5M people afflicted in CA alone in 8 weeks... stated on March 19th. |
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04-04-2020, 3:37pm | #197 | ||||||
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04-04-2020, 3:40pm | #198 | ||||||
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04-04-2020, 3:44pm | #199 | |||||||
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Until antibody testing is widely collected, will not have a good idea on true “infected” numbers. What we can look at currently, is the survival rate of those that become symptomatic and critically ill. |
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04-04-2020, 3:46pm | #200 | ||||||
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