Pixel density is a real-world concern. Using a full frame sensor - 36mm x 24mm- The 5D MK IV is 30MP. That's a specific number of pixels spread across a predetermined area. (The sensor)
Now take a 5DS at 50MP. This sensor crams 20 more MP into the same area. BFD right? Not exactly. Higher MP *generally* means poorer low light performance. And for me this is the big one; More megapixels mean those smaller pixels are more susceptible to camera shake.
Using my 5D MK IV and R5 as an example. I could routinely and consistently capture BIF at 1/1600 to 1/2000 second on the 5D MK IV. The added pixels of the R5 however forced me to bump my shutter up to 1/2500 to achieve the same number of keepers. On the R5 @ 1/1600 my keeper rate becomes inconsistent. And I'm pretty damn steady. (all those years welding probably had some impact on steadiness I'm imagining)
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