Yes, it is possible.
However, Vbulletin advises to NOT set it that way because of the threaded display option (set in your UserCP).
The reason being, is "the click" attaches your quick reply to a specific post...This is meaningless in the linear view (default view setting) because your reply will always appear next in the thread after submitting your post.
However, it will not in the threaded view because of the system "not knowing" what is a reply to what post.
In the threaded mode, everything acts like a quote reply, except without the quoted content. You can see who was replying to what post. (if that makes sense to you).
I suspect very few (if any) actually use the threaded or hybrid view options, so if the decision is made to change to the "no click" quick reply, we will also disable the option of using threaded/hybrid views.
Would like to hear some more opinions about this before changing it, but I kinda doubt anyone will have an objection.