No experience with Cologuard, but I had the procedure done and highly recommend you do the same. During the exam, if they find any polyps (somewhat common) they can remove them immediately before they can potentially develop into something more serious.
Drug store kits are fine if you want to whiten your teeth or see if you're pregnant. This is a lot more important, and in my opinion, family history isn't a good enough reason to leave things to chance.
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