View Full Version : Wegovy, Ozempic linked with sight-threatening eye disorder in study
Seems your eyes need a little cholesterol to work right, who knew? Maybe that's why they can't eat a whole pizza, they can't see it. FYI, wife out of town and ordered a pizza since I haven't had one in months. Only managed to down three slices and that third one went down hard, I'm a failure. I need Ozempic.
The rate of the eye problem known as nonarteritic anterior ischemic optic neuropathy, or NAION, was 8.9% for those taking semaglutide for type 2 diabetes, compared with 1.8% for patients taking non-GLP-1 diabetes medications, researchers reported in JAMA Ophthalmology.
Among those prescribed semaglutide for overweight or obesity, the rate of the eye condition was 6.7%, versus 0.8% for those receiving other types of medications for weight reduction.
https://www.yahoo.com/news/wegovy-ozempic-linked-sight-threatening-152955598.html?fr=sycsrp_catchall
Vandelay Industries
07-05-2024, 6:39pm
Gastroparesis and blindness?
Shut up and take my money!
Gastroparesis and blindness?
Shut up and take my money!:rofl:
Every cell in our bodies require cholesterol to work properly. If there isn't enough in the diet, our bodies produce it.
Easiest and healthiest way to lose weight is to go on the carnivore diet for max weight loss, keto-carnivore ("keto-vore") for lesser problems. Eat all you want, pig out every day, and the excess fat will disappear.
lrobe22
07-05-2024, 6:47pm
Taking pills to lose weight is never a good idea.
My SIL, yesterday at the 4th feast actually said that sugar doesn't cause/contribute to diabetes or weight gain.
All talking came to a halt and we all just looked at her and shook our heads.
TheHammer
07-05-2024, 10:18pm
Small price to pay to be a skinny, blind corpse.
Tikiman
07-06-2024, 5:37am
On the bright side, if you are a Tesla owner, you will no longer be able to see just how ugly your car is. :island14:
Someone wants to drive down the Daily Price of the Rx Maker's ( Novo Nordisk ) Stock Price at the Opening Bell on Monday with this Media Bought " Study "
Price of NVO 142. per share ~ Up 63 YoY ( Year over Year - fer ya common folk )
The they'll Swoop in ~ buy a bunch low ~ Then . . .
Watch it Skyrocket after an Rx of NVO's is approved for all Gov't Funded Rx Plans next week . . .
Paulie P & Nancy P ~ We on to You . . .
Watch NVO Drop to 130 in the first hour ~ then it'll go back up to 142 at EoD ( End of Day for ya common folk )
Then Skyrocket later in H2 ( 2nd Half of 20124 fer ya common folk )
105696
AND . . following A/E's Pro Market Tips based on his Astute Observations
GrandSportC3
07-06-2024, 6:10am
Every drug you can take may have side effects. Most of the time, side effects only affect a relatively small percent. My Cholesterol, while lower with Ozempic is neither high nor low and I take Omega 3 supplements as well. I'm 53 and don't need glasses. Not a lot of 53 year olds that don't need any glasses. Had my latest eye exam earlier this year.
BTW, I'm no longer obese. 214 lbs this morning. Down 32 lbs from 246lbs in 2020.
"High cholesterol" is not a disease.
GrandSportC3
07-06-2024, 6:14am
"High cholesterol" is not a disease.
High bad cholesterol can cause plaque build up in your arteries and can lead to heart attack.
High bad cholesterol can cause plaque build up in your arteries and can lead to heart attack.
That is simply not true, but that is what you've been told by the same people/establishment that said "This vaccine will prevent you from getting or spreading Covid."
Every drug you can take may have side effects.
EVERYTHING has side effects. For instance, I started eating better and exercising more. And out of nowhere I lost weight and felt better. It was the damnedest thing.
GrandSportC3
07-06-2024, 8:49am
That is simply not true, but that is what you've been told by the same people/establishment that said "This vaccine will prevent you from getting or spreading Covid."
So, Dr. Bruze, what causes clogged arteries leading to heart attack?
Tikiman
07-06-2024, 8:55am
That is simply not true, but that is what you've been told by the same people/establishment that said "This vaccine will prevent you from getting or spreading Covid."
You mean that isn't true? :willy::rofl:
KenHorse
07-06-2024, 9:20am
My SIL, yesterday at the 4th feast actually said that sugar doesn't cause/contribute to diabetes or weight gain.
All talking came to a halt and we all just looked at her and shook our heads.
She's kinda correct about that but left out "in moderation"
On the bright side, if you are a Tesla owner, you will no longer be able to see just how ugly your car is. :island14:
And...you'll still be able to use FSD.
So, Dr. Bruze, what causes clogged arteries leading to heart attack?
Inflammation in your arteries that allow the LDL to form calcifications. It's not the cholesterol itself.
GrandSportC3
07-06-2024, 10:26am
Inflammation in your arteries that allow the LDL to form calcifications. It's not the cholesterol itself.
Sure, but there are many things that can cause inflammation of your arteries including different diseases. It's safer to have low LDL and high HDL in case you have inflammation of your arteries.
A friend of mine who is an athlete and eats very healthy (low carb diet) had 2 heart attacks at age 55.
His Cholesterol was over 300. He never tested for it due to his healthy lifestyle.
https://bmjopensem.bmj.com/content/4/1/e000429
lrobe22
07-06-2024, 11:06am
My SIL, yesterday at the 4th feast actually said that sugar doesn't cause/contribute to diabetes or weight gain.
All talking came to a halt and we all just looked at her and shook our heads.
pics of SIL?
dvarapala
07-06-2024, 11:12am
My SIL, yesterday at the 4th feast actually said that sugar doesn't cause/contribute to diabetes or weight gain.
All talking came to a halt and we all just looked at her and shook our heads.
Is she related to Matt Gruber? :shrug:
dvarapala
07-06-2024, 11:14am
High bad cholesterol can cause plaque build up in your arteries and can lead to heart attack.
Wrong.
Cholesterol is the body's repair mechanism for inflammation. A high level of cholesterol is a symptom, not a cause.
Taurus
07-06-2024, 12:10pm
Sure, but there are many things that can cause inflammation of your arteries including different diseases. It's safer to have low LDL and high HDL in case you have inflammation of your arteries.
A friend of mine who is an athlete and eats very healthy (low carb diet) had 2 heart attacks at age 55.
His Cholesterol was over 300. He never tested for it due to his healthy lifestyle.
https://bmjopensem.bmj.com/content/4/1/e000429
You need to stop, I know this topic too well as I've been working between patients and doctors leading the heart disease forums for IB for many, many years. I read the studies and know much of the data.
To your point, I know people in perfect health and low LDL that have died of heart attacks as well. Inflammation is the key, statins help bring down blood levels of CRP as well as limit production of LDL. Researchers believe that statins block the proteins and immune cells that are released as part of the body's normal inflammation process. Lowering these protein levels effectively prevents inflammation from occurring. Inflammation gives LDL a place to settle, much like a sluice box gathers gold in it's ripples.
It's not just how much LDL in your system, it's how much small particle LDL, how much HDL (natural HDL, not induced by medications like Niacin) and how much inflammation in your arteries. Those are the factors make up your heart disease risk. The reason type 2 diabetics have a higher risk of heart disease is the inflammation the diabetes cause in the vascular system.
TheHammer
07-06-2024, 1:06pm
You need to stop, I know this topic too well as I've been working between patients and doctors leading the heart disease forums for IB for many, many years. I read the studies and know much of the data.
To your point, I know people in perfect health and low LDL that have died of heart attacks as well. Inflammation is the key, statins help bring down blood levels of CRP as well as limit production of LDL. Researchers believe that statins block the proteins and immune cells that are released as part of the body's normal inflammation process. Lowering these protein levels effectively prevents inflammation from occurring. Inflammation gives LDL a place to settle, much like a sluice box gathers gold in it's ripples.
It's not just how much LDL in your system, it's how much small particle LDL, how much HDL (natural HDL, not induced by medications like Niacin) and how much inflammation in your arteries. Those are the factors make up your heart disease risk. The reason type 2 diabetics have a higher risk of heart disease is the inflammation the diabetes cause in the vascular system.
*riffles
My SIL, yesterday at the 4th feast actually said that sugar doesn't cause/contribute to diabetes or weight gain.
All talking came to a halt and we all just looked at her and shook our heads.
She is probably a Biden voter.
She is probably a Biden voter.
:yesnod:
*riffles
Thanks, I had no idea that's what they were called. :seasix:
I can use that analogy correctly going forward.
I just think it's cool that even if you get really, really fat, if you have a Tesla, it doesn't matter. It's so fast it can easily pull the extra weight with no issue. :yesnod:
Thanks, I had no idea that's what they were called. :seasix:
I can use that analogy correctly going forward.
Don't worry, it'll all pan out.
Don't worry, it'll all pan out.
:rofl: That was good.
vettemed
07-06-2024, 3:16pm
I just think it's cool that even if you get really, really fat, if you have a Tesla, it doesn't matter. It's so fast it can easily pull the extra weight with no issue. :yesnod:
It's that instant torque, yaknow.
ratflinger
07-06-2024, 3:46pm
Might be good if ft people can't see the table.
GrandSportC3
07-06-2024, 4:32pm
You need to stop, I know this topic too well as I've been working between patients and doctors leading the heart disease forums for IB for many, many years. I read the studies and know much of the data.
To your point, I know people in perfect health and low LDL that have died of heart attacks as well. Inflammation is the key, statins help bring down blood levels of CRP as well as limit production of LDL. Researchers believe that statins block the proteins and immune cells that are released as part of the body's normal inflammation process. Lowering these protein levels effectively prevents inflammation from occurring. Inflammation gives LDL a place to settle, much like a sluice box gathers gold in it's ripples.
It's not just how much LDL in your system, it's how much small particle LDL, how much HDL (natural HDL, not induced by medications like Niacin) and how much inflammation in your arteries. Those are the factors make up your heart disease risk. The reason type 2 diabetics have a higher risk of heart disease is the inflammation the diabetes cause in the vascular system.
This makes sense but why are physicians checking those cholesterol levels if they are really irrelevant or almost irrelevant when it comes to heart disease? Shouldn't they be checking for the other factors you pointed out?
This makes sense but why are physicians checking those cholesterol levels if they are really irrelevant or almost irrelevant when it comes to heart disease? Shouldn't they be checking for the other factors you pointed out?
They do, part of almost all blood screening tests includes a C-Reactive Protein (CRP) that measures the amount of inflammation in your vascular system and active tissue damage taking place in your body.
If I may add; most doctors today are trained by big pharma.
We don't have a Healthcare system, we have a sick care system.
If I may add; most doctors today are trained by big pharma.
We don't have a Healthcare system, we have a sick care system.
DING DING DING!
I have a Master's degree in statistics, and understand the "Framingham Study" that supported the development of "Statins" to "lower serum cholesterol" in an effort to prevent heart attacks. Sparing you the technical details, the "Framingham Study" is a common example used in higher level statistics courses to demonstrate what happens when you violate the parameters of a mathematical construct (in this case a multiple regression). Basically the conclusions of that study DO NOT support the idea that lowering serum cholesterol levels will prevent, or even delay, your first heart attack.
My current GP has been pushing the statins on me for years because my total cholesterol runs at about 220, and she wants all kinds of ridiculous numbers. I have asked her to explain her position vis-a-vis the Framingham study for years, and she declined. Last year, she started talking about my cholesterol, and I asked her again to give me her view on the Framingham study, and she said "I don't want to talk about the Framingham study."
I haven't heard a word from her about statins since. :yesnod:
Don't even get me started on the three point safety harness required on all new vehicles and its relationship to your front airbag (that kills a lot of people).
DING DING DING!
I have a Master's degree in statistics, and understand the "Framingham Study" that supported the development of "Statins" to "lower serum cholesterol" in an effort to prevent heart attacks. Sparing you the technical details, the "Framingham Study" is a common example used in higher level statistics courses to demonstrate what happens when you violate the parameters of a mathematical construct (in this case a multiple regression). Basically the conclusions of that study DO NOT support the idea that lowering serum cholesterol levels will prevent, or even delay, your first heart attack.
My current GP has been pushing the statins on me for years because my total cholesterol runs at about 220, and she wants all kinds of ridiculous numbers. I have asked her to explain her position vis-a-vis the Framingham study for years, and she declined. Last year, she started talking about my cholesterol, and I asked her again to give me her view on the Framingham study, and she said "I don't want to talk about the Framingham study."
I haven't heard a word from her about statins since. :yesnod:
Don't even get me started on the three point safety harness required on all new vehicles and its relationship to your front airbag (that kills a lot of people).
You are correct, the key number in Framingham is the Number Needed to Treat or NNT. This represents the number of patients needed to be treated to get one positive out come, that number is 50 across all groups. Doctors like to throw the Jupiter trial out there as it has an NNT of 20 but that study is flawed as it was ended early due to very promising results so they could get Crestor on the market sooner.
The Framingham risk score is a useful tool to help stratify cardiovascular risk, not for what the threshold for statin use should be. Statins have a place for folk predisposed to heart disease like diabetics or those that have had previous/current heart disease, not for everyone with a slightly elevated total cholesterol level.
dvarapala
07-06-2024, 6:39pm
I just think it's cool that even if you get really, really fat, if you have a Tesla, it doesn't matter. It's so fast it can easily pull the extra weight with no issue. :yesnod:
That's why the Model X is Oliver's Forever Car. Even if he goes off Ozempic he's covered. :D
You are correct, the key number in Framingham is the Number Needed to Treat or NNT. This represents the number of patients needed to be treated to get one positive out come, that number is 50 across all groups. Doctors like to throw the Jupiter trial out there as it has an NNT of 20 but that study is flawed as it was ended early due to very promising results so they could get Crestor on the market sooner.
The Framingham risk score is a useful tool to help stratify cardiovascular risk, not for what the threshold for statin use should be. Statins have a place for folk predisposed to heart disease like diabetics or those that have had previous/current heart disease, not for everyone with a slightly elevated total cholesterol level.
I am correct, but you are not. The problem with the Framingham study is purely mathematical. When you perform a multiple regression, in order for your results to be mathematically valid, you MUST first test for something called "multi-collinearity". Once again, saving a long-winded explanation of the mathematics, the regressors must NOT be highly correlated with each other, since if they are, ALL of the statistical results are invalid.
The Framingham study results as published, are NOTHING short of GIGO = Garbage in = Garbage out.
Worthless, plain and simple.
Study after study has shown that there is no statistically significant relationship between serum cholesterol levels (at least prior to the first heart attack) and heart disease. The reason is that there is an extremely high correlation between serum cholesterol levels and hypertension. Because they are so highly correlated, the mathematics of the multiple regression were violated, and the results as stated are mathematically meaningless.
Subsequent studies have proven beyond all reasonable mathematical doubt that controlling hypertension, at the very least, will delay a person's first heart attack. Because of this, I am VERY focused on controlling my hypertension!
Subsequent studies have also repeatedly shown that simply lowering serum cholesterol levels through the use of statins, has a number needed to treat of well over 100. Meaning, if you are not diabetic, nor have hypertension, but have "high" cholesterol, you have a less than 1% chance that statins will help you at all, but at least a 15% chance of suffering negative side effects of the medication.
Bad medicine. :yesnod:
If you have any doubt, simply look at how the definition of "high cholesterol" has changed over the years. Big pharma knows this shit doesn't work, and has been trying to find a level of serum cholesterol that will provide a significant benefit. They have yet to succeed. :yesnod:
OK.
Back in the real life of people, if you want to know the state of your cardiac artery health , a simple and cheap way to assess is to get a calcium scan done.
GrandSportC3
07-06-2024, 8:25pm
They do, part of almost all blood screening tests includes a C-Reactive Protein (CRP) that measures the amount of inflammation in your vascular system and active tissue damage taking place in your body.
Checked my healthcare app and that test was never requested for me.
Frankie the Fink
07-07-2024, 6:01am
Name some of these big pharma drug cocktails that do NOT have a side effect, and significant ones in many cases.
Remember fen-phen for weight loss in the 90s ?
Doctors handing it out like candy and it was killing people.
DJ_Critterus
07-07-2024, 8:25am
Seems your eyes need a little cholesterol to work right, who knew? Maybe that's why they can't eat a whole pizza, they can't see it. FYI, wife out of town and ordered a pizza since I haven't had one in months. Only managed to down three slices and that third one went down hard, I'm a failure. I need Ozempic.
The rate of the eye problem known as nonarteritic anterior ischemic optic neuropathy, or NAION, was 8.9% for those taking semaglutide for type 2 diabetes, compared with 1.8% for patients taking non-GLP-1 diabetes medications, researchers reported in JAMA Ophthalmology.
Among those prescribed semaglutide for overweight or obesity, the rate of the eye condition was 6.7%, versus 0.8% for those receiving other types of medications for weight reduction.
https://www.yahoo.com/news/wegovy-ozempic-linked-sight-threatening-152955598.html?fr=sycsrp_catchall
And here I was thinking GSC3 was blind only because his head was rammed up his ass.... :willy:
Frankie the Fink
07-07-2024, 3:31pm
Having had 7 eye surgeries (a combo of cataract surgery and bad genetics) and nearly blind in the left eye and 20/40 in the right eye, on a good day, in sunshine I wouldn't take anything with above a ZERO chance of affecting the most important of the 5 senses. EVERYthing in my life has been affected in one way or another.
Having had 7 eye surgeries (a combo of cataract surgery and bad genetics) and nearly blind in the left eye and 20/40 in the right eye, on a good day, in sunshine I wouldn't take anything with above a ZERO chance of affecting the most important of the 5 senses. EVERYthing in my life has been affected in one way or another.
I totally agree with you.
Having had 7 eye surgeries (a combo of cataract surgery and bad genetics) and nearly blind in the left eye and 20/40 in the right eye, on a good day, in sunshine I wouldn't take anything with above a ZERO chance of affecting the most important of the 5 senses. EVERYthing in my life has been affected in one way or another.
I totally agree with you.
As do I. One thing GS is right about is that EVERY medication any of us takes has the potential for nasty side effects. That is why I don't take medications for "convenience". My doctor has offered me Ozempic every time I have been there for the last year or so, and I always turn it down.
It has been a challenge, but I have gotten very slowly leaner over the last few years without any drugs to "help" me achieve my fitness goals. I don't expect pats on the back for it, because that is what I am supposed to be doing. I'm not one of those guys who expects praise because they pay their bills or take care of their kids etc.
If people want to take a "short cut", and are willing to risk blindness as a result, hey, it's their vision. :shrug:
Swany00
07-07-2024, 3:50pm
no statins for us ever, fkn doctors and pharmacy are still trying to coerce me to take the shingles vaccine too....done with them all
no statins for us ever, fkn doctors and pharmacy are still trying to coerce me to take the shingles vaccine too....done with them all
I wish the best for you:cert:. I had shingles years back before the shots came out and its real nasty. I'm up to date on my shingles shots.
GrandSportC3
07-08-2024, 6:14am
As do I. One thing GS is right about is that EVERY medication any of us takes has the potential for nasty side effects. That is why I don't take medications for "convenience". My doctor has offered me Ozempic every time I have been there for the last year or so, and I always turn it down.
It has been a challenge, but I have gotten very slowly leaner over the last few years without any drugs to "help" me achieve my fitness goals. I don't expect pats on the back for it, because that is what I am supposed to be doing. I'm not one of those guys who expects praise because they pay their bills or take care of their kids etc.
If people want to take a "short cut", and are willing to risk blindness as a result, hey, it's their vision. :shrug:
Talking about vision.. I'm 53 and still don't need glasses, even for reading. Had an eye exam a few months back and everything was great. My regular doctor actually ordered me to get one as I have NEVER ever been to an opteometrist because I have great vision. My regular Dr. said that elevated A1C can affect vision but it seems that I have not had any issues with my vision.
Talking about vision.. I'm 53 and still don't need glasses, even for reading. Had an eye exam a few months back and everything was great. My regular doctor actually ordered me to get one as I have NEVER ever been to an opteometrist because I have great vision. My regular Dr. said that elevated A1C can affect vision but it seems that I have not had any issues with my vision.
When I was a freshman in college, I had trouble studying for long periods, and found out that I was a little far-sighted, and got reading glasses. I had to move up a strength when I was about 40, and again a few years ago, but still only use 1.5s, which are fairly weak. I am 60. My distance vision is still better than 20/20, just like it always has been.
Not sure where you are going with this, but there is zero doubt that diabetes can cause blindness. Additionally, I'm not taking ANY medication if I don't need it for something, not worth the risk of the side effects just to convenience myself.
SnikPlosskin
07-09-2024, 9:49pm
I’ve never taken any of that shit but eyes going bad is no joke. I don’t post much because my eyesight has deteriorated a lot over the last year. I’m trying to adapt but it’s coming on fast (immune system attacking my optic nerves according to doc.). He said I need to prepare for being legally blind in 4-5 years.
I’m driving my wife nuts because I can’t read the tv scroll on the news or descriptions on streaming channels. I’m supposed to start learning braille at some point but that shit is hard.
Getting old sucks.
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